Top PageDivision of Basic MedicineCell Science Integrative Physiology/Imaging Physiology

Cell Science

Integrative Physiology/Imaging Physiology

Research

   Our research focuses on the brain circuit mechanisms that regulate homeostatic physiological functions in mammals, particularly focusing on body temperature regulation and autonomic stress responses. The homeostatic regulatory functions are essential to our life, particularly to survive a variety of environmental stressors.  By combining classic methodologies (e.g., in vivo physiology, electrophysiology and neuroanatomy) with state-of-the-art technologies (e.g., optogenetics and pharmacogenetics), we are pursuing the core mechanisms and principles in the central circuit systems maintaining homeostasis.  We believe that our basic research on the fundamental mechanisms of homeostasis would have big impacts on broad areas of clinical researches.  
   We also study the cellular and molecular mechanisms by which cells sense and respond to mechanical stresses, such as stretch, pressure and gravity.  In this project, we use a single-molecular imaging technique and also contribute to a space biology project.


For detailed research information, please visit our original website:
http://www.med.nagoya-u.ac.jp/physiol2/english.html

Courses for graduate students

Master's degree is an academic degree granted to individuals who have undergone study demonstrating a mastery or high-order overview of a specific field of study or area of professional practice. The Master's degree is a 2-year program designed specifically to prepare careers in Physiology and Neuroscience. Students receive training in the major subject areas: Physiology, Neuroanatomy, Biotechnology, and Imaging techniques.


Ph.D. is an advanced academic degree awarded by universities. The Nagoya University Graduate School of Medicine offers a four-year Ph.D. program, leading to a Ph.D. degree.  The Ph.D. program is intended to provide opportunities of training as medical researchers, and our laboratory accepts Ph.D. students who aim to develop their careers in Physiology, Neuroanatomy, Biotechnology, and Imaging techniques.


Applicants for these graduate programs should have a strong background in Life Science (anatomy, biochemistry, biology, medicine, microbiology, molecular biology, pharmacology, and physiology).  Please contact us:


Contact:
Kazuhiro Nakamura, Professor <kazu@med.nagoya-u.ac.jp>
Department of Integrative Physiology
Nagoya University Graduate School of Medicine
65 Tsurumai-cho, Nagoya 466-8550, Japan
Phone: +81-52-744-2052, Fax:+81-52-744-2056
 

Major publications

Nakamura, Y., Yanagawa, Y., Morrison, S.F. & Nakamura, K.*
Medullary reticular neurons mediate neuropeptide Y-induced metabolic inhibition and mastication.
Cell Metab. in press, 2017. PubMed


Nakamura, K.*
Neural circuit for psychological stress-induced hyperthermia.
Temperature 2:352-361, 2015. Publisher


Kataoka, N., Hioki, H., Kaneko, T. & Nakamura, K.*
Psychological stress activates a dorsomedial hypothalamus–medullary raphe circuit driving brown adipose tissue thermogenesis and hyperthermia.
Cell Metab. 20:346-358, 2014. PubMed


Lkhagvasuren, B., Oka, T., Nakamura, Y., Hayashi, N., Sudo, N. & Nakamura, K.*
Distribution of Fos-immunoreactive cells in rat forebrain and midbrain following social defeat stress and diazepam treatment.
Neuroscience 272:34-57, 2014. PubMed


Nakamura, K.*
Central circuitries for body temperature regulation and fever.
Am. J. Physiol. 301:R1207-R1228, 2011. PubMed


Lkhagvasuren, B., Nakamura, Y., Oka, T., Sudo, N. & Nakamura, K.*
Social defeat stress induces hyperthermia through activation of thermoregulatory sympathetic premotor neurons in the medullary raphe region.
Eur. J. Neurosci. 34:1442-1452, 2011. PubMed


Nakamura, K.* & Morrison, S.F.
Central efferent pathways for cold-defensive and febrile shivering.
J. Physiol. 589:3641-3658, 2011. PubMed


Nakamura, K.* & Morrison, S.F.
A Thermosensory pathway mediating heat-defense responses.
Proc. Natl. Acad. Sci. U.S.A. 107:8848-8853, 2010. PubMed


Nakamura, Y., Nakamura, K.* & Morrison, S.F.
Different populations of prostaglandin EP3 receptor-expressing preoptic neurons project to two fever-mediating sympathoexcitatory brain regions.
Neuroscience 161:614-620, 2009. PubMed


Nakamura, K.* & Morrison, S.F.
Preoptic mechanism for cold-defensive responses to skin cooling.
J. Physiol. 586:2611-2620, 2008. PubMed


Nakamura, K.* & Morrison, S.F.
A thermosensory pathway that controls body temperature.
Nature Neurosci. 11:62-71, 2008. PubMed


Nakamura, K.* & Morrison, S.F.
Central efferent pathways mediating skin cooling-evoked sympathetic thermogenesis in brown adipose tissue.
Am. J. Physiol. 292:R127-R136, 2007. PubMed


Nakamura, K.*#, Yamashita, Y.#, Tamamaki, N., Katoh, H., Kaneko, T. & Negishi, M.
In vivo function of Rnd2 in the development of neocortical pyramidal neurons.
Neurosci. Res. 54:149-153, 2006. (#, equal contribution) PubMed


Nakamura, Y., Nakamura, K.*, Matsumura, K., Kobayashi, S., Kaneko, T. & Morrison, S.F.
Direct pyrogenic input from prostaglandin EP3 receptor-expressing preoptic neurons to the dorsomedial hypothalamus.
Eur. J. Neurosci. 22:3137-3146, 2005. PubMed


Nakamura, K.*, Matsumura, K., Hübschle, T., Nakamura, Y., Hioki, H., Fujiyama, F., Boldogkoi, Z., Konig, M., Thiel, H.-J., Gerstberger, R., Kobayashi, S. & Kaneko, T.
Identification of sympathetic premotor neurons in medullary raphe regions mediating fever and other thermoregulatory functions.
J. Neurosci. 24:5370-5380, 2004. PubMed


Nakamura, K.*, Wu, S.-X., Fujiyama, F., Okamoto, K., Hioki, H. & Kaneko, T.
Independent inputs by VGLUT2- and VGLUT3-positive glutamatergic terminals onto rat sympathetic preganglionic neurons.
NeuroReport 15:431-436, 2004. PubMed


Nakamura, K.*, Matsumura, K., Kaneko, T., Kobayashi, S., Katoh, H. & Negishi, M.
The rostral raphe pallidus nucleus mediates pyrogenic transmission from the preoptic area.
J. Neurosci. 22:4600-4610, 2002. PubMed


Nakamura, K.*, Li, Y.-Q., Kaneko, T., Katoh, H. & Negishi, M.
Prostaglandin EP3 receptor protein in serotonin and catecholamine cell groups: a double immunofluorescence study in the rat brain.
Neuroscience 103:763-775, 2001. PubMed


Nakamura, K.*, Kaneko, T., Yamashita, Y., Hasegawa, H., Katoh, H. & Negishi, M.
Immunohistochemical localization of prostaglandin EP3 receptor in the rat nervous system.
J. Comp. Neurol. 421:543-569, 2000. PubMed


Nakamura, K., Kaneko, T., Yamashita, Y., Hasegawa, H., Katoh, H., Ichikawa, A. & Negishi, M.*
Immunocytochemical localization of prostaglandin EP3 receptor in the rat hypothalamus.
Neurosci. Lett. 260:117-120, 1999. PubMed


Our full publication list is available at our original website.

 


Faculty

Faculty Post Department
Kazuhiro Nakamura
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ProfessorDepartment of Integrative Physiology
Takeshi Kobayashi
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Senior LecturerDepartment of Integrative Physiology
Yoshiko Nakamura
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Assistant ProfessorDepartment of Integrative Physiology
Naoya Kataoka
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Assistant ProfessorDepartment of Integrative Physiology
Manami Oya
ResearcherDepartment of Integrative Physiology
Tomoko Nagai
SecretaryDepartment of Integrative Physiology