トップページ研究室紹介(基礎医学領域)微生物・免疫学 分子細胞免疫学/免疫細胞動態学(免疫学)

微生物・免疫学

分子細胞免疫学/免疫細胞動態学(免疫学)

免疫と疾患

医学的に重要な疾患の免疫学的解析を通して、疾患の病態形成、回復過程における免疫系の役割を明らかにする。

構成員名/英名表記 役職 所属
西川博嘉/Hiroyoshi Nishikawa
詳しくはこちら→
教授
鈴木治彦/Haruhiko suzuki
詳しくはこちら→
准教授免疫学会
伊藤佐知子/Sachiko Ito
詳しくはこちら→
講師免疫学会、基礎老化学会
Kochin Vitaly
詳しくはこちら→
特任助教
分子細胞免疫学
分子動態免疫学

論文業績

2013

  Ito S, Nishio N,Tanaka Y, Thanasegaran S, Isobe K. Establishment of self-renewable GM-CSF-dependent immature macrophages in vitro from murine bone marrow. PLOS ONE in press.

 Thanasegaran S, Cheng Z, Ito S, Nishio N, Isobe K. No immunogenicity of IPS cells in syngeneic host studied by in vivo injection and 3D scaffold experiments. Biomed Res Int. 2013;2013:378207.

  Okuno Y, Murakoshi A, Negita M, Akane K, Kojima S, Suzuki H.

CD8+ CD122+ regulatory T cells contain clonally expanded cells with identical CDR3 sequences of the T-cell receptor β-chain.

Immunology. 2013 Jul;139(3):309-17.

  Kito T, Shibata R, Ishii M, Suzuki H, Himeno T, Kataoka Y, Yamamura Y, Yamamoto T, Nishio N, Ito S, Numaguchi Y, Tanigawa T, Yamashita JK, Ouchi N, Honda H, Isobe K, Murohara T. iPS cell sheets created by a novel magnetite tissue engineering method for reparative angiogenesis. Sci Rep. 2013;3:1418.

  Cheng Z, Ito S, Nishio N, Thanasegaran S, Fang H, Isobe K. Characteristics of cardiac aging in C57BL/6 mice. Exp Gerontol. 2013 Mar;48(3):341-8.

 

2012

     Okawa T, Kamiya H, Himeno T, Kato J, Seino Y, Fujiya A, Kondo M, Tsunekawa S, Naruse K, Hamada Y, Ozaki N, Cheng Z, Kito T, Suzuki H, Ito S, Oiso Y, Nakamura J, Isobe KI. Transplantation of Neural Crest Like Cells Derived from induced Pluripotent Stem Cells Improves Diabetic Polyneuropathy in Mice. Cell Transplant. 2012 Oct 8. doi: 10.3727/096368912X657710. [Epub ahead of print]

    Isobe K, Cheng Z, Ito S, Nishio N. Aging in the mouse and perspectives of rejuvenation through induced pluripotent stem cells (iPSCs). Results Probl Cell Differ. 2012;55:413-27. Review.

    Suzuki H, Shibata R, Kito T, Yamamoto T, Ishii M, Nishio N, Ito S, Isobe K, Murohara T. Comparative angiogenic activities of induced pluripotent stem cells derived from young and old mice. PLoS One. 2012;7(6):e39562. doi: 10.1371

    Isobe K, Cheung HS, Wu J. Toward personalized cell therapies by using stem cells. J Biomed Biotechnol. 2012;2012:172564.

    Klionsky DJ,---- Isobe K. ----.Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy. 2012 Apr;8(4):445-544.

    Hara M, Nishio N, Ito S, Akiyama M, Isobe K. Up-regulation of Gr1+CD11b+ cell population in the spleen of NaClO-administered mice works to repair skin woundsBiodiscovery 2012; 2: 1.

    Uddin MN, Nishio N, Ito S, Suzuki H, Isobe K. Autophagic activity in thymus and liver during aging. Age (Dordr). 2012 Feb;34(1):75-85.

 

2011

     Uddin MN, Ito S, Nishio N, Suganya T, Isobe K. Gadd34 induces autophagy through the suppression of the mTOR pathway during starvation. Biochem Biophys Res Commun. 2011 Apr 22;407(4):692-8.

     Zhang R, Ito S, Nishio N, Cheng Z, Suzuki H, Isobe KI. Dextran sulphate sodium increases splenic Gr1(+)CD11b(+) cells which accelerate recovery from colitis following intravenous transplantation. Clin Exp Immunol. 2011 Jun;164(3):417-27.

     Miura H, Ando Y, Noda Y, Isobe K, Ozaki N. Long-lasting effects of inescapable-predator stress on brain tryptophan metabolism and the behavior of juvenile mice. Stress. 2011 May;14(3):262-72.

     Cheng Z, Ito S, Nishio N, Xiao H, Zhang R, Suzuki H, Okawa Y, Murohara T, Isobe K. Establishment of induced pluripotent stem cells from aged mice using bone marrow-derived myeloid cells. J Mol Cell Biol. 2011 Apr;3(2):91-8.

     Zhang R, Ito S, Nishio N, Cheng Z, Suzuki H, Isobe K. Up-regulation of Gr1+CD11b+ population in spleen of dextran sulfate sodium administered mice works to repair colitis. Inflamm Allergy Drug Targets. 2011 Feb;10(1):39-46.

     Endharti AT, Okuno Y, Shi Z, Misawa N, Toyokuni S, Ito M, Isobe K, Suzuki H. CD8+CD122+ regulatory T cells (Tregs) and CD4+ Tregs cooperatively prevent and cure CD4+ cell-induced colitis. J Immunol. 2011 Jan 1;186(1):41-52.

     Inami Y, Yoshikai T, Ito S, Nishio N, Suzuki H, Sakurai H, Isobe K. Differentiation of induced pluripotent stem cells to thymic epithelial cells by phenotype. Immunol Cell Biol. 2011 Feb;89(2):314-21.

2010年

Suzuki H, Shibata R, Kito T, Ishii M, Li P, Yoshikai T, Nishio N, Ito S, Numaguchi Y, Yamashita JK, Murohara T, Isobe K. Therapeutic angiogenesis by transplantation of induced pluripotent stem cell-derived Flk-1 positive cells. BMC Cell Biol. 2010 Sep 22;11:72.

Inami Y, Yoshikai T, Ito S, Nishio N, Suzuki H, Sakurai H, Isobe KI. Differentiation of induced pluripotent stem cells to thymic epithelial cells by phenotype. Immunol Cell Biol. 2010 Aug 3. [Epub ahead of print]

Tanaka C, Ito S, Nishio N, Kodera Y, Sakurai H, Suzuki H, Nakao A, Isobe K. GADD34 suppresses wound healing by upregulating expression of myosin IIA. Transgenic Res. 2010 Aug;19(4):637-45.

Uddin MN, Nishio N, Ito S, Suzuki H, Isobe K. Toxic effects of D-galactose on thymus and spleen that resemble aging. J Immunotoxicol. 2010 Jul-Sep;7(3):165-73.


2009年

Nishio N, Ito S, Suzuki H, Isobe K. Antibodies to wounded tissue enhance cutaneous wound healing. Nishio N, Ito S, Suzuki H, Isobe K. Immunology. 2009 Nov;128(3):369-80.

Ogasawara N, Oguro T, Sakabe T, Matsushima M, Takikawa O, Isobe K, Nagase F. Hemoglobin induces the expression of indoleamine 2,3-dioxygenase in dendritic cells through the activation of PI3K, PKC, and NF-kappaB and the generation of reactive oxygen species. J Cell Biochem. 2009 Oct 15;108(3):716-25.

Matsumoto N, Okochi M, Matsushima M, Kato R, Takase T, Yoshida Y, Kawase M, Isobe K, Kawabe T, Honda H. Peptide array-based analysis of the specific IgE and IgG4 in cow's milk allergens and its use in allergy evaluation. Peptides. 2009 Oct;30(10):1840-7.

Shi Z, Okuno Y, Rifa'i M, Endharti AT, Akane K, Isobe K, Suzuki H. Human CD8+CXCR3+ T cells have the same function as murine CD8+CD122+ Treg. Eur J Immunol. 2009 Aug;39(8):2106-19.

Matsumoto N, Okochi M, Matsushima M, Ogawa A, Takase T, Yoshida Y, Kawase M, Isobe K, Kawabe T, Honda H. Development of peptide arrays for detection of IgE-binding epitopes in cow's milk allergens. J Biosci Bioeng. 2009 Mar;107(3):324-30.

Ishikawa H, Ito S, Nishio N, Yuzawa Y, Matsuo S, Isobe K. Injection of bleomycin in newborn mice induces autoimmune sialitis that is transferred by CD4 T cells. Immunol Cell Biol. 2009 May-Jun;87(4):351-8.

Ishikawa H, Takeda K, Okamoto A, Matsuo S, Isobe K. Induction of autoimmunity in a bleomycin-induced murine model of experimental systemic sclerosis: an important role for CD4+ T cells. J Invest Dermatol. 2009 Jul;129(7):1688-95.

Ishida Y, Kozaki T, Isomura Y, Ito S, Isobe K. Age-dependent changes in dopaminergic neuron firing patterns in substantia nigra pars compacta. J Neural Transm Suppl. 2009;(73):129-33.

Miura H, Shirokawa T, Isobe K, Ozaki N. Shifting the balance of brain tryptophan metabolism elicited by isolation housing and systemic administration of lipopolysaccharide in mice. Stress. 2009;12(3):206-14.


2008年

Kobayashi T, Okamoto S, Hisamatsu T, Kamada N, Chinen H, Saito R, Kitazume MT, Nakazawa A, Sugita A, Koganei K, Isobe K, Hibi T.IL23 differentially regulates the Th1/Th17 balance in ulcerative colitis and Crohn's disease. Gut. 2008 Dec;57(12):1682-9.

Miura H, Ozaki N, Shirokawa T, Isobe K.Changes in brain tryptophan metabolism elicited by ageing, social environment, and psychological stress in mice.Stress. 2008;11(2):160-9.

Miura H, Ozaki N, Sawada M, Isobe K, Ohta T, Nagatsu T.

A link between stress and depression: shifts in the balance between the kynurenine and serotonin pathways of tryptophan metabolism and the etiology and pathophysiology of depression. Stress. 2008;11(3):198-209.

Yoshida N, Ino K, Ishida Y, Kajiyama H, Yamamoto E, Shibata K, Terauchi M, Nawa A, Akimoto H, Takikawa O, Isobe K, Kikkawa F.

Overexpression of indoleamine 2,3-dioxygenase in human endometrial carcinoma cells induces rapid tumor growth in a mouse xenograft model.

Clin Cancer Res. 2008 Nov 15;14(22):7251-9.

Suzuki H, Shi Z, Okuno Y, Isobe K. Are CD8+CD122+ cells regulatory T cells or memory T cells?

Hum Immunol. 2008 Nov;69(11):751-4. Review.

Sasaki S, Ishida Y, Nishio N, Ito S, Isobe K.Thymic involution correlates with severe ulcerative colitis induced by oral administration of dextran sulphate sodium in C57BL/6 mice but not in BALB/c mice.

Inflammation. 2008 Oct;31(5):319-28.

Rifa'i M, Shi Z, Zhang SY, Lee YH, Shiku H, Isobe K, Suzuki H.

CD8+CD122+ regulatory T cells recognize activated T cells via conventional MHC class I-alphabetaTCR interaction and become IL-10-producing active regulatory cells.Int Immunol. 2008 Jul;20(7):937-47.

Kimura K, Ito S, Nagino M, Isobe K.Inhibition of reactive oxygen species down-regulates protein synthesis in RAW 264.7.Biochem Biophys Res Commun. 2008 Jul 18;372(1):272-5.

Sakurai H, Okawa Y, Inami Y, Nishio N, Isobe K.

Paraxial mesodermal progenitors derived from mouse embryonic stem cells contribute to muscle regeneration via differentiation into muscle satellite cells.Stem Cells. 2008 Jul;26(7):1865-73.

 

Nishio N, Okawa Y, Sakurai H, Isobe K.Neutrophil depletion delays wound repair in aged mice. Age (Dordr). 2008 Mar;30(1):11-9.

Shi Z, Rifa'i M, Lee YH, Shiku H, Isobe K, Suzuki H.

Importance of CD80/CD86-CD28 interactions in the recognition of target cells by CD8+CD122+ regulatory T cells. Immunology. 2008 May;124(1):121-8.

Hara T, Ogasawara N, Akimoto H, Takikawa O, Hiramatsu R, Kawabe T, Isobe K, Nagase F.

High-affinity uptake of kynurenine and nitric oxide-mediated inhibition of indoleamine 2,3-dioxygenase in bone marrow-derived myeloid dendritic cells.Immunol Lett. 2008 Feb 15;116(1):95-102.

Lee YH, Ishida Y, Rifa'i M, Shi Z, Isobe K, Suzuki H.

Essential role of CD8+CD122+ regulatory T cells in the recovery from experimental autoimmune encephalomyelitis.J Immunol. 2008 Jan 15;180(2):825-32.

Hara T, Yamakura F, Takikawa O, Hiramatsu R, Kawabe T, Isobe K, Nagase F.

Diazotization of kynurenine by acidified nitrite secreted from indoleamine 2,3-dioxygenase-expressing myeloid dendritic cells.

J Immunol Methods. 2008 Mar 20;332(1-2):162-9.

Hiramatsu R, Hara T, Akimoto H, Takikawa O, Kawabe T, Isobe K, Nagase F.

Cinnabarinic acid generated from 3-hydroxyanthranilic acid strongly induces apoptosis in thymocytes through the generation of reactive oxygen species and the induction of caspase.

J Cell Biochem. 2008 Jan 1;103(1):42-53.

Miura H, Ozaki N, Shirokawa T, Isobe K. Changes in brain tryptophan metabolism elicited by ageing, social environment, and psychological stress in mice.Stress. 2008;11(2):160-9.


2007年

Ishida Y, Okawa Y, Ito S, Shirokawa T, Isobe K.

Age-dependent changes in dopaminergic projections from the substantia nigra pars compacta to the neostriatum.

Neurosci Lett. 2007 May 18;418(3):257-61.

Ito S, Kimura K, Haneda M, Ishida Y, Sawada M, Isobe K.

Induction of matrix metalloproteinases (MMP3, MMP12 and MMP13) expression in the microglia by amyloid-beta stimulation via the PI3K/Akt pathway. Exp Gerontol. 2007 Jun;42(6):532-7.

Ujike-Asai A, Okada A, Du Y, Maruyama M, Yuan X, Ishikawa F, Motoo Y, Isobe K, Nakajima H.

Large defects of type I allergic response in telomerase reverse transcriptase knockout mice.

J Leukoc Biol. 2007 Aug;82(2):429-35.

Minami K, Tambe Y, Watanabe R, Isono T, Haneda M, Isobe KI, Kobayashi T, Hino O, Okabe H, Chano T, Inoue H. Suppression of Viral Replication by Stress-inducible GADD34 via the mTOR Pathway. J Virol. 2007 Oct;81(20):11106-15. 

Watanabe R, Tambe Y, Inoue H, Isono T, Haneda M, Isobe K, Kobayashi T, Hino O, Okabe H, Chano T. GADD34 inhibits mammalian target of rapamycin signaling via tuberous sclerosis complex and controls cell survival under bioenergetic stress. Int J Mol Med. 2007 Mar;19(3):475-83.

Minami K, Inoue H, Terashita T, Kawakami T, Watanabe R, Haneda M, Isobe K, Okabe H, Chano T. GADD34 induces p21 expression and cellular senescence. Oncol Rep. 2007 Jun;17(6):1481-5.


2006年

Ito S, Sawada M ,Haneda M, Ishida Y, Isobe KI.      Amyloid-beta peptides induce several chemokine mRNA expressions in the primary microglia and Ra2 cell line via the PI3K/Akt and/or ERK pathway. Neurosci Res. 2006  2006 Nov;56(3):294 9.

Kato M, Takeda K, Kawamoto Y, Tsuzuki T, Kato Y, Ohno T, Hossain K, Iftakhar-E- Khuda I, Ohgami N, Isobe KI, Takahashi M, Nakashima I.     Novel Hairless RET-Transgenic Mouse Line with Melanocytic Nevi and Anagen Hair Follicles. J Invest Dermatol. 2006 Nov;126(11):2547-50.

Nakai S, Matsunaga W, Isobe K, Shirokawa T. Age-dependent interactive changes in serotonergic and noradrenergic cortical axon terminals in F344 rats.  Neurosci Res. 2006 Mar;54(3):220-229.

Matsunaga W, Isobe K, Shirokawa T. Involvement of neurotrophic factors in aging of noradrenergic innervations in hippocampus and frontal cortex. Neurosci Res. 2006 Jan 28;

Takeda K, Kawamoto Y, Okuno Y, Kato M, Takahashi M, Suzuki H, Isobe K, Nakashima I. A PKC-mediated backup mechanism of the MXXCW motif-linked switch for initiating tyrosine kinase activities.FEBS Lett. 2006 Feb 6;580(3):839-43.

Isobe K, Ito S, Haneda M, Ishida Y.    Cellular and systemic defense system against age-promoting stimuli.Nagoya J Med Sci. 2006 Jan;68(1-2):9-18.