トップページ研究室紹介(臨床医学領域)病態医療学(協力) 細胞治療医学((病)輸血部)

病態医療学(協力)

細胞治療医学((病)輸血部)

附属病院 診療部へはこちら 「輸血部」

教員

構成員名/英名表記 役職 所属
松下 正/Tadashi Matsushita
詳しくはこちら→
教授附属病院輸血部
山本 晃士/YAMAMOTO Koji
詳しくはこちら→
講師附属病院輸血部

研究分野紹介

機能構築医学専攻・病態医療学(協力)・細胞治療医学 骨髄および末梢血中に存在する幹細胞の多分化能を利用して、以下の疾患を対象とした基礎研究と先進的治療を行っている。
1 血液悪性腫瘍(白血病、リンパ腫)や固形癌に対するミニ移植療法
2 末梢動脈閉塞性疾患に対する血管再生治療
3 心血管の動脈硬化症(狭心症、心筋梗塞)に対する血管新生治療

研究キーワード

再生医療、造血幹細胞、出血性素因、血栓性素因、肝炎ウイルス

研究業績

  1. Numaguchi Y, Ishii M, Kubota R, Morita Y, Yamamoto K, Matsushita T, Okumura K, Murohara T. Ablation of angiotensin IV receptor attenuates hypofibrinolysis via PAI-1 downregulation and reduces occlusive arterial thrombosis. Arterioscler Thromb Vasc Biol 2009; 29: 2102-8.

  2. Kashiwagi T, Matsushita T, Ito Y, Hirashima K, Sanda N, Fujimori Y, Yamada T, Okumura K, Takagi A, Murate T, Katsumi A, Takamatsu J, Yamamoto K, Naoe T, Kojima T. L1503R is a member of group I mutation and has dominant-negative effect on secretion of full-length VWF multimers: an analysis of two patients with type 2A von Willebrand disease. Haemophilia 2008; 14: 556-563.

  3. Yanada M, Matsushita T, Asou N, Kishimoto Y, Tsuzuki M, Maeda Y, Horikawa K, Okada M, Ohtake S, Yagasaki F, Matsumoto T, Kimura Y, Shinagawa K, Iwanaga M, Miyazaki Y, Ohno R, Naoe T. Severe hemorrhagic complications during remission induction therapy for acute promyelocytic leukemia: incidence, risk factors, and influence on outcome. Eur J Haematol 2007; 78: 213-9.

  4. Fontayne A, De Maeyer B, De Maeyer M, Yamashita M, Matsushita T, Deckmyn H. Paratope and epitope mapping of the antithrombotic antibody 6B4 in complex with platelet glycoprotein Ibalpha. J Biol Chem 2007; 282: 23517-24.

  5. Matsushita T, Saito H. Abnormal hemostasis tests and bleeding in chronic liver disease: are they related? No, but they need a careful look. J Thromb Haemost 2006; 4: 2066-7.

  6. Yamamoto K, Honda T, Matsushita T, Kojima T, Takamatsu J. Anti-HCV agent, ribavirin, elevates the activity of clotting factor VII in hemophilia patients: a possible mechanism of decreased events of bleeding in hemophiliacs by ribavirin J Thromb Haemost 2006;4:469-470.

  7. Hayashi M, Matsushita T, Mackman N, Ito M, Adachi T, Katsumi A, Yamamoto K, Takeshita K, Kojima T, Saito H, Murohara T, Naoe T. Fatal thrombosis of antithrombin deficient mice is rescued differently in the heart and liver by intercrossing with low tissue factor mice. J Thromb Haemost 2006;4:177-185.

  8. Yamamoto K, Kojima T, Adachi T, Hayashi M, Matsushita T, Takamatsu J, Loskutoff DJ, Saito H. Obesity enhances the induction of plasminogen activator inhibitor-1 by restraint stress: a possible mechanism of stress-induced renal fibrin deposition in obese mice. J Thromb Haemost 2005;3:1495-1502.

  9. Honda T, Toyoda H, Hayashi K, Katano Y, Yano M, Nakano I, Yoshioka K, Goto H, Yamamoto K, Takamatsu J. Ribavirin and the use of clotting factors in hemophilia patients with chronic hepatitis C. JAMA 2005;293:1190-1192.

  10. Yamamoto K, Takeshita K, Kojima T, Takamatsu J, Saito H. Aging and PAI-1 regulation: Implication in the pathogenesis of thrombotic disorders in the elderly. Cardiovasc Res 2005;66:276-285.

  11. Yamamoto K, Kondo T, Suzuki S, Izawa H, Kobayashi M, Emi N, Komori K, Naoe T, Takamatsu J, Murohara T. Molecular evaluationof endothelial progenitor cells in patients with ischemic limbs: therapeutic effect by stem cell transplantation. Arterioscler Thromb Vasc Biol 2004;24:e192-e196.

  12. Ando F, Tsuzuki T, Mizuno T, Minami M, Ina K, Kusugami K, Takamtsu J, Adachi K, El-Omar E, Ohta M, Goto H. Characterrisitics of Heicobactor pyrori-induced gastritis and the effect of H. Pylori eradication in patients with chronic idiopathic thrombocytopenic purpura. Helicobactor 2004;9:443-445.

  13. Matsushita T, Hayashi H, Kunishima S, Hayashi M, Ikejiri M, Takeshita K, Yuzawa Y, Adachi T, Hirashima K, Sone M, Yamamoto K, Takagi A, Katsumi A, Kawai K, Nezu T, Takahashi M, Nakashima T, Naoe T, Kojima T, Saito H. Targeted disruption of mouse ortholog of the human MYH9 responsible for macrothrombocytopenia with different organ involvement: hematological, nephrological, and otological studies of heterozygous KO mice. Biochem Biophys Res Commun 2004; 325: 1163-71.

  14. Yanada M, Kojima T, Ishiguro K, Nakayama Y, Yamamoto K, Matsushita T, Kadomatsu K, Nishimura M, Muramatsu T, Saito H. Impact of antithrombin deficiency in thrombogenesis: lipopolysaccharide and stress-induced thrombus formation in heterozygous antithrombin- deficient mice. Blood 2002; 99: 2455-8.

  15. Matsushita T, Meyer D, Sadler JE. Localization of von willebrand factor-binding sites for platelet glycoprotein Ib and botrocetin by charged-to-alanine scanning mutagenesis. J Biol Chem 2000; 275: 11044-9.